Microwave alkylation of lithium tetrazolate

نویسندگان

  • Danny Müller
  • Christian Knoll
  • Peter Weinberger
چکیده

ABSTRACT N1-substituted tetrazoles are interesting ligands in transition metal coordination chemistry, especially in the field of spin crossover. Their synthesis is performed in most cases according to the Franke-synthesis, using a primary amine as reagent introducing the substitution pattern. To enhance flexibility in means of substrate scope, we developed a new protocol based on alkylation of lithium tetrazolate with alkyl bromides. The N1-N2 isomerism of the tetrazole during the alkylation was successfully suppressed by use of highly pure lithium tetrazolate and 30 vol.% aqueous ethanol as solvent, leading to pure N1-substituted products. The feasibility of this reaction was demonstrated by a selection of different substrates. GRAPHICAL ABSTRACT

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عنوان ژورنال:

دوره 148  شماره 

صفحات  -

تاریخ انتشار 2017